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The stdio (standard input/output) transport is the default one in Agno’s integration. It works best for local integrations. To use it, simply initialize the MCPTools class with the command argument. The command you want to pass is the one used to run the MCP server the agent will have access to. For example uvx mcp-server-git, which runs a git MCP server: 
from agno.agent import Agent
from agno.models.openai import OpenAIChat
from agno.tools.mcp import MCPTools

# Initialize and connect to the MCP server
# Can also use custom binaries: command="./my-mcp-server"
mcp_tools = MCPTools(command="uvx mcp-server-git")
await mcp_tools.connect()

try:
    agent = Agent(model=OpenAIChat(id="gpt-5-mini"), tools=[mcp_tools])
    await agent.aprint_response("What is the license for this project?", stream=True)
finally:
    # Always close the connection when done
    await mcp_tools.close()
You can also use multiple MCP servers at once, with the MultiMCPTools class. For example: 
import asyncio
import os

from agno.agent import Agent
from agno.tools.mcp import MultiMCPTools


async def run_agent(message: str) -> None:
    """Run the Airbnb and Google Maps agent with the given message."""

    env = {
        **os.environ,
        "GOOGLE_MAPS_API_KEY": os.getenv("GOOGLE_MAPS_API_KEY"),
    }

    # Initialize and connect to multiple MCP servers
    mcp_tools = MultiMCPTools(
        commands=[
            "npx -y @openbnb/mcp-server-airbnb --ignore-robots-txt",
            "npx -y @modelcontextprotocol/server-google-maps",
        ],
        env=env,
    )
    await mcp_tools.connect()

    try:
        agent = Agent(
            tools=[mcp_tools],
            markdown=True,
        )

        await agent.aprint_response(message, stream=True)
    finally:
        # Always close the connection when done
        await mcp_tools.close()


# Example usage
if __name__ == "__main__":
    # Pull request example
    asyncio.run(
        run_agent(
            "What listings are available in Cape Town for 2 people for 3 nights from 1 to 4 August 2025?"
        )
    )
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